SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory.

SDF-1a Degrades whereas Glycoprotein 120 Upregulates Bcl-2 Interacting Mediator of Death Extralong Isoform: Implications for the Development of T Cell Memory

مقایسه سطح سرمی کموکین SDF-1α در بیماران مبتلا به سکته قلبی و افراد غیرمبتلا به سکته قلبی

Background and purpose: Çardiovascular diseases are the most common causes of death in Ïran as well as in the world. SDF-1a, as an effective chemokine for decreasing inflammation and injury, plays a role in angiogenesis. This study compares and evaluates serum level of this chemokine in healthy people and those with ÂMÏ (Âcute Myocardial Ïnfarction) regarding age and gender. Materials and me...

Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps

Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R injury in ischemic free flaps. Free flaps that underwent ischemia for 3 h were...

بررسی الگوی تغییرات سطح سرمیSDF-1α و IP-10 در مدل حیوانی سگ متعاقب ایجاد انفارکتوس تجربی میوکارد

  Background and Objectives : Since chemokines expression is one of the most inflammatory responses to injury in the myocardium , this project was aimed to find out the pattern of expression of SDF-1 and IP-10 in dog model of experimental ischemia to extend the results of this model to clinical applications.   Material and Methods: In this experimental study eighteen male dogs aged (6 - 12 mont...

Exosomal lipids induce human pancreatic tumoral MiaPaCa-2 cells resistance through the CXCR4-SDF-1α signaling axis

We previously reported that exosomes secreted by human pancreatic tumor cells induce cell death through the inhibition of the Notch-1 survival pathway (Ristorcelli et al., 2009). We demonstrated that exosomal lipids evoked apoptosis of human pancreatic cancer SOJ-6 cells. Based on the lipid composition of efficient exosomes we designed Synthetic Exosome-Like Nanoparticles (SELN) in which the ra...